Transformation of hematopoietic cell lines to growth-factor independence and induction of a fatal myelo- and lymphoproliferative disease in mice by retrovirally transduced TEL/JAK2 fusion genes.

Recent reports have demonstrated fusion of the TEL gene on 12p13 to the JAK2 gene on 9p24 in human leukemias. Three variants have been identified that fuse the TEL pointed (PNT) domain to (i) the JAK2 JH1-kinase domain, (ii) part of and (iii) all of the JH2 pseudokinase domain. We report that all of...

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Detalhes bibliográficos
Main Authors: Schwaller, J, Frantsve, J, Aster, J, Williams, I R, Tomasson, M H, Ross, T S, Peeters, P, Van Rompaey, L, Van Etten, R A, Ilaria, R, Marynen, P, Gilliland, D G
Formato: Artigo
Idioma:Inglês
Publicado em: 1998
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1170859/
https://ncbi.nlm.nih.gov/pubmed/9736611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/17.18.5321
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