Structural analysis of the GAP-related domain from neurofibromin and its implications.

Neurofibromin is the product of the NF1 gene, whose alteration is responsible for the pathogenesis of neurofibromatosis type 1 (NF1), one of the most frequent genetic disorders in man. It acts as a GTPase activating protein (GAP) on Ras; based on homology to p120GAP, a segment spanning 250-400 aa an...

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Detalhes bibliográficos
Main Authors: Scheffzek, K, Ahmadian, M R, Wiesmüller, L, Kabsch, W, Stege, P, Schmitz, F, Wittinghofer, A
Formato: Artigo
Idioma:Inglês
Publicado em: 1998
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1170765/
https://ncbi.nlm.nih.gov/pubmed/9687500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/17.15.4313
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