Structural analysis of the Ras-like G protein MglA and its cognate GAP MglB and implications for bacterial polarity

The bacterium Myxococcus xanthus uses a G protein cycle to dynamically regulate the leading/lagging pole polarity axis. The G protein MglA is regulated by its GTPase-activating protein (GAP) MglB, thus resembling Ras family proteins. Here, we show structurally and biochemically that MglA undergoes a...

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Main Authors: Miertzschke, Mandy, Koerner, Carolin, Vetter, Ingrid R, Keilberg, Daniela, Hot, Edina, Leonardy, Simone, Søgaard-Andersen, Lotte, Wittinghofer, Alfred
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3199381/
https://ncbi.nlm.nih.gov/pubmed/21847100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.291
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