Allelic exchange at the endogenous genomic locus in Plasmodium falciparum proves the role of dihydropteroate synthase in sulfadoxine-resistant malaria.

We have exploited the recently developed ability to trans- fect the malaria parasite Plasmodium falciparum to investigate the role of polymorphisms in the enzyme dihydropteroate synthase (DHPS), identified in sulfadoxine-resistant field isolates. By using a truncated form of the dhps gene, specific...

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Detalhes bibliográficos
Main Authors: Triglia, T, Wang, P, Sims, P F, Hyde, J E, Cowman, A F
Formato: Artigo
Idioma:Inglês
Publicado em: 1998
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1170716/
https://ncbi.nlm.nih.gov/pubmed/9669998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/17.14.3807
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