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p53 facilitates pRb cleavage in IL-3-deprived cells: novel pro-apoptotic activity of p53.
In the interleukin-3 (IL-3)-dependent lymphoid cell line DA-1, functional p53 is required for efficient apoptosis in response to IL-3 withdrawal. Activation of p53 in these cells, by either DNA damage or p53 overexpression, results in a vital growth arrest in the presence of IL-3 and in accelerated...
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
1998
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1170695/ https://ncbi.nlm.nih.gov/pubmed/9649429 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/17.13.3587 |
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