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Genetic selection of intragenic suppressor mutations that reverse the effect of common p53 cancer mutations.
Several lines of evidence suggest that the presence of the wild-type tumor suppressor gene p53 in human cancers correlates well with successful anti-cancer therapy. Restoration of wild-type p53 function to cancer cells that have lost it might therefore improve treatment outcomes. Using a systematic...
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| Hlavní autoři: | , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
1998
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1170532/ https://ncbi.nlm.nih.gov/pubmed/9524109 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/17.7.1847 |
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