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Genetic selection of intragenic suppressor mutations that reverse the effect of common p53 cancer mutations.

Several lines of evidence suggest that the presence of the wild-type tumor suppressor gene p53 in human cancers correlates well with successful anti-cancer therapy. Restoration of wild-type p53 function to cancer cells that have lost it might therefore improve treatment outcomes. Using a systematic...

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Detalhes bibliográficos
Main Authors: Brachmann, R K, Yu, K, Eby, Y, Pavletich, N P, Boeke, J D
Formato: Artigo
Idioma:Inglês
Publicado em: 1998
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1170532/
https://ncbi.nlm.nih.gov/pubmed/9524109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/17.7.1847
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