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High efficiency detection of bi-stranded abasic clusters in γ-irradiated DNA by putrescine

Bi-stranded abasic clusters, an abasic (AP) site on one DNA strand and another nearby AP site or strand break on the other, have been quantified using Nfo protein from Escherichia coli to produce a double-strand break at cluster sites. Since recent data suggest that Nfo protein cleaves inefficiently...

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Detalhes bibliográficos
Main Authors: Georgakilas, Alexandros G., Bennett, Paula V., Sutherland, Betsy M.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2002
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC117048/
https://ncbi.nlm.nih.gov/pubmed/12087163
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