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Processing of bistranded abasic DNA clusters in γ-irradiated human hematopoietic cells

Clustered DNA damages—two or more lesions on opposing strands and within one or two helical turns—are formed in cells by ionizing radiation or radiomimetic antitumor drugs. They are hypothesized to be difficult to repair, and thus are critical biological damages. Since individual abasic sites can be...

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Autors principals: Georgakilas, Alexandros G., Bennett, Paula V., Wilson, David M., Sutherland, Betsy M.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2004
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC524283/
https://ncbi.nlm.nih.gov/pubmed/15494449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkh871
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