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Processing of bistranded abasic DNA clusters in γ-irradiated human hematopoietic cells

Clustered DNA damages—two or more lesions on opposing strands and within one or two helical turns—are formed in cells by ionizing radiation or radiomimetic antitumor drugs. They are hypothesized to be difficult to repair, and thus are critical biological damages. Since individual abasic sites can be...

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Detalhes bibliográficos
Main Authors: Georgakilas, Alexandros G., Bennett, Paula V., Wilson, David M., Sutherland, Betsy M.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2004
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC524283/
https://ncbi.nlm.nih.gov/pubmed/15494449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkh871
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