The coactivator TIF2 contains three nuclear receptor-binding motifs and mediates transactivation through CBP binding-dependent and -independent pathways.

The nuclear receptor (NR) coactivator TIF2 possesses a single NR interaction domain (NID) and two autonomous activation domains, AD1 and AD2. The TIF2 NID is composed of three NR-interacting modules each containing the NR box motif LxxLL. Mutation of boxes I, II and III abrogates TIF2-NR interaction...

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Detalhes bibliográficos
Main Authors: Voegel, J J, Heine, M J, Tini, M, Vivat, V, Chambon, P, Gronemeyer, H
Formato: Artigo
Idioma:Inglês
Publicado em: 1998
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1170401/
https://ncbi.nlm.nih.gov/pubmed/9430642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/17.2.507
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