Defective B cell receptor-mediated responses in mice lacking the Ets protein, Spi-B.

Spi-B is a hematopoietic-specific Ets family transcription factor closely related to PU.1. Previous gene targeting experiments have shown that PU.1 is essential for the production of both lymphocytes and monocytes. We have now generated mice with a null mutation at the Spi-B locus. Unlike PU.1 mutan...

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Bibliographic Details
Main Authors: Su, G H, Chen, H M, Muthusamy, N, Garrett-Sinha, L A, Baunoch, D, Tenen, D G, Simon, M C
Format: Artigo
Language:Inglês
Published: 1997
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1170313/
https://ncbi.nlm.nih.gov/pubmed/9384589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/16.23.7118
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