Defective immune responses in mice lacking LUBAC-mediated linear ubiquitination in B cells

The linear ubiquitin chain assembly complex (LUBAC) plays a crucial role in activating the canonical NF-κB pathway, which is important for B-cell development and function. Here, we describe a mouse model (B-HOIP(Δlinear)) in which the linear polyubiquitination activity of LUBAC is specifically ablat...

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Autori principali: Sasaki, Yoshiteru, Sano, Soichi, Nakahara, Masaki, Murata, Shigeo, Kometani, Kohei, Aiba, Yuichi, Sakamoto, Shinji, Watanabe, Yoshihiro, Tanaka, Keiji, Kurosaki, Tomohiro, Iwai, Kazuhiro
Natura: Artigo
Lingua:Inglês
Pubblicazione: European Molecular Biology Organization 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3770953/
https://ncbi.nlm.nih.gov/pubmed/23942237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2013.184
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