Inhibition of NF-kappa-B cellular function via specific targeting of the I-kappa-B-ubiquitin ligase.

Activation of the transcription factor NF-kappa B is a paradigm for signal transduction through the ubiquitin-proteasome pathway: ubiquitin-dependent degradation of the transcriptional inhibitor I kappa B in response to cell stimulation. A major issue in this context is the nature of the recognition...

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Autors principals: Yaron, A, Gonen, H, Alkalay, I, Hatzubai, A, Jung, S, Beyth, S, Mercurio, F, Manning, A M, Ciechanover, A, Ben-Neriah, Y
Format: Artigo
Idioma:Inglês
Publicat: 1997
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1170254/
https://ncbi.nlm.nih.gov/pubmed/9351830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/16.21.6486
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