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Regulation of stability and function of the epithelial Na+ channel (ENaC) by ubiquitination.

The epithelial Na+ channel (ENaC), composed of three subunits (alpha beta gamma), plays a critical role in salt and fluid homeostasis. Abnormalities in channel opening and numbers have been linked to several genetic disorders, including cystic fibrosis, pseudohypoaldosteronism type I and Liddle synd...

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Autores principales: Staub, O, Gautschi, I, Ishikawa, T, Breitschopf, K, Ciechanover, A, Schild, L, Rotin, D
Formato: Artigo
Lenguaje:Inglês
Publicado: 1997
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1170239/
https://ncbi.nlm.nih.gov/pubmed/9351815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/16.21.6325
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