High mobility group chromosomal protein 1 binds to the adeno-associated virus replication protein (Rep) and promotes Rep-mediated site-specific cleavage of DNA, ATPase activity and transcriptional repression.

High mobility group protein 1 (HMG1) is an abundant non-histone chromosomal protein which plays a role in several nuclear events involving DNA. Here we demonstrate that HMG1 physically interacts with the human adeno-associated virus (AAV) Rep protein. HMG1 promotes the formation of Rep-DNA complexes...

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Detalhes bibliográficos
Main Authors: Costello, E, Saudan, P, Winocour, E, Pizer, L, Beard, P
Formato: Artigo
Idioma:Inglês
Publicado em: 1997
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1170225/
https://ncbi.nlm.nih.gov/pubmed/9312052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/16.19.5943
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