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S-acylation of LCK protein tyrosine kinase is essential for its signalling function in T lymphocytes.

LCK is a non-receptor protein tyrosine kinase required for signal transduction via the T-cell antigen receptor (TCR). LCK N-terminus is S-acylated on Cys3 and Cys5, in addition to its myristoylation on Gly2. Here the role of S-acylation in LCK function was examined. Transient transfection of COS-18...

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Main Authors: Kabouridis, P S, Magee, A I, Ley, S C
Formato: Artigo
Idioma:Inglês
Publicado: 1997
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1170133/
https://ncbi.nlm.nih.gov/pubmed/9305640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/16.16.4983
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