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S-acylation of LCK protein tyrosine kinase is essential for its signalling function in T lymphocytes.
LCK is a non-receptor protein tyrosine kinase required for signal transduction via the T-cell antigen receptor (TCR). LCK N-terminus is S-acylated on Cys3 and Cys5, in addition to its myristoylation on Gly2. Here the role of S-acylation in LCK function was examined. Transient transfection of COS-18...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
1997
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1170133/ https://ncbi.nlm.nih.gov/pubmed/9305640 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/16.16.4983 |
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