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The chaperonin cycle cannot substitute for prolyl isomerase activity, but GroEL alone promotes productive folding of a cyclophilin-sensitive substrate to a cyclophilin-resistant form.

The chaperonin GroEL and the peptidyl-prolyl cis-trans isomerase cyclophilin are major representatives of two distinct cellular systems that help proteins to adopt their native three-dimensional structure: molecular chaperones and folding catalysts. Little is known about whether and how these protei...

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Bibliografske podrobnosti
Main Authors: von Ahsen, O, Tropschug, M, Pfanner, N, Rassow, J
Format: Artigo
Jezik:Inglês
Izdano: 1997
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1170083/
https://ncbi.nlm.nih.gov/pubmed/9303301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/16.15.4568
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