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Structure of the PH domain and Btk motif from Bruton's tyrosine kinase: molecular explanations for X-linked agammaglobulinaemia.

Bruton's tyrosine kinase (Btk) is an enzyme which is involved in maturation of B cells. It is a target for mutations causing X-linked agammaglobulinaemia (XLA) in man. We have determined the structure of the N-terminal part of Btk by X-ray crystallography at 1.6 A resolution. This part of the k...

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書誌詳細
主要な著者: Hyvönen, M, Saraste, M
フォーマット: Artigo
言語:Inglês
出版事項: 1997
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC1169965/
https://ncbi.nlm.nih.gov/pubmed/9218782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/16.12.3396
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