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Targeted expression of MYCN causes neuroblastoma in transgenic mice.
The proto-oncogene MYCN is often amplified in human neuroblastomas. The assumption that the amplification contributes to tumorigenesis has never been tested directly. We have created transgenic mice that overexpress MYCN in neuroectodermal cells and develop neuroblastoma. Analysis of tumors by compa...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
1997
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1169917/ https://ncbi.nlm.nih.gov/pubmed/9214616 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/16.11.2985 |
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