FLICE is activated by association with the CD95 death-inducing signaling complex (DISC).

Upon activation, the apoptosis-inducing cell membrane receptor CD95 (APO-1/Fas) recruits a set of intracellular signaling proteins (CAP1-4) into a death-inducing signaling complex (DISC). In the DISC, CAP1 and CAP2 represent FADD/MORT1. CAP4 was identified recently as an ICE-like protease, FLICE, wi...

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Detalhes bibliográficos
Main Authors: Medema, J P, Scaffidi, C, Kischkel, F C, Shevchenko, A, Mann, M, Krammer, P H, Peter, M E
Formato: Artigo
Idioma:Inglês
Publicado em: 1997
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1169888/
https://ncbi.nlm.nih.gov/pubmed/9184224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/16.10.2794
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