Dynamics within the CD95 death-inducing signaling complex decide life and death of cells

This study explores the dilemma in cellular signaling that triggering of CD95 (Fas/APO-1) in some situations results in cell death and in others leads to the activation of NF-κB. We established an integrated kinetic mathematical model for CD95-mediated apoptotic and NF-κB signaling. Systematic model...

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Библиографические подробности
Главные авторы: Neumann, Leo, Pforr, Carina, Beaudouin, Joel, Pappa, Alexander, Fricker, Nicolai, Krammer, Peter H, Lavrik, Inna N, Eils, Roland
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group 2010
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2858442/
https://ncbi.nlm.nih.gov/pubmed/20212524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/msb.2010.6
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