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RIO: Analyzing proteomes by automated phylogenomics using resampled inference of orthologs

BACKGROUND: When analyzing protein sequences using sequence similarity searches, orthologous sequences (that diverged by speciation) are more reliable predictors of a new protein's function than paralogous sequences (that diverged by gene duplication). The utility of phylogenetic information in...

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Detalhes bibliográficos
Main Authors: Zmasek, Christian M, Eddy, Sean R
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2002
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC116988/
https://ncbi.nlm.nih.gov/pubmed/12028595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2105-3-14
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