Initiation of V(D)J recombination in vivo: role of recombination signal sequences in formation of single and paired double-strand breaks.

In V(D)J recombination, double-strand breaks (DSBs) are introduced at recombination signal sequences (RSSs) which consist of three distinct elements: a heptamer, a 12 or 23 nucleotide spacer and a nonamer. Efficient DSB formation requires a 12/23 RSS pair and occurs at both RSS in a temporally coupl...

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Bibliographic Details
Main Authors: Steen, S B, Gomelsky, L, Speidel, S L, Roth, D B
Format: Artigo
Language:Inglês
Published: 1997
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1169876/
https://ncbi.nlm.nih.gov/pubmed/9184212
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/16.10.2656
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