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Initiation of V(D)J recombination in vivo: role of recombination signal sequences in formation of single and paired double-strand breaks.
In V(D)J recombination, double-strand breaks (DSBs) are introduced at recombination signal sequences (RSSs) which consist of three distinct elements: a heptamer, a 12 or 23 nucleotide spacer and a nonamer. Efficient DSB formation requires a 12/23 RSS pair and occurs at both RSS in a temporally coupl...
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| Autores principales: | , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
1997
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1169876/ https://ncbi.nlm.nih.gov/pubmed/9184212 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/16.10.2656 |
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