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Activation of c-Raf-1 by Ras and Src through different mechanisms: activation in vivo and in vitro.
The c-Raf-1 protein kinase plays a critical role in intracellular signaling downstream from many tyrosine kinase and G-protein-linked receptors. c-Raf-1 binds to the proto-oncogene Ras in a GTP-dependent manner, but the exact mechanism of activation of c-Raf-1 by Ras is still unclear. We have establ...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
1997
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1169839/ https://ncbi.nlm.nih.gov/pubmed/9171352 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/16.9.2384 |
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