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Identification of HuR as a protein implicated in AUUUA-mediated mRNA decay.

Expression of many proto-oncogenes, cytokines and lymphokines is regulated by targeting their messenger RNAs for rapid degradation. Essential signals for this control are AU-rich elements (AREs) in the 3' untranslated region (UTR) of these messages. The ARE is loosely defined as the five-nucleo...

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Hlavní autoři: Myer, V E, Fan, X C, Steitz, J A
Médium: Artigo
Jazyk:Inglês
Vydáno: 1997
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1169815/
https://ncbi.nlm.nih.gov/pubmed/9155038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/16.8.2130
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