Targeted Deletion of the Integrin β4 Signaling Domain Suppresses Laminin-5-Dependent Nuclear Entry of Mitogen-Activated Protein Kinases and NF-κB, Causing Defects in Epidermal Growth and Migration

The α6β4 integrin—a laminin-5 receptor—mediates assembly of hemidesmosomes and recruitment of Shc and phosphoinositide 3-kinase through the unique cytoplasmic extension of β4. Mice carrying a targeted deletion of the signaling domain of β4 develop normally and do not display signs of skin fragility....

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Bibliographic Details
Main Authors: Nikolopoulos, Sotiris N., Blaikie, Pamela, Yoshioka, Toshiaki, Guo, Wenjun, Puri, Claudia, Tacchetti, Carlo, Giancotti, Filippo G.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2005
Subjects:
Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1168825/
https://ncbi.nlm.nih.gov/pubmed/15988021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.14.6090-6102.2005
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