RNA-Dependent Protein Kinase Is Required for Alpha-1 Interferon Transgene-Induced Resistance to Genital Herpes Simplex Virus Type 2

We investigated the mechanism of resistance to genital herpes simplex virus type 2 (HSV-2) infection in mice transfected with the murine alpha-1 interferon (IFN-α1) transgene. In situ transfection of mice with the IFN-α1 transgene resulted in an elevation in an IFN-responsive gene, RNA-dependent pro...

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Detalhes bibliográficos
Main Authors: Carr, Daniel J. J., Tomanek, Lisa, Silverman, Robert H., Campbell, Iain L., Williams, Bryan R. G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1168756/
https://ncbi.nlm.nih.gov/pubmed/15994831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.14.9341-9345.2005
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