The lack of RNA-dependent protein kinase enhances susceptibility of mice to genital herpes simplex virus type 2 infection

Mice deficient in RNA-dependent protein kinase (PKR(–/–)) or deficient in PKR and a functional 2′,5′-oligoadenylate synthetase (OAS) pathway (PKR/RL(–/–)) are more susceptible to genital herpes simplex virus type 2 (HSV-2) infection than wild-type mice or mice that are deficient only in a functional...

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Bibliographic Details
Main Authors: Carr, Daniel J J, Wuest, Todd, Tomanek, Lisa, Silverman, Robert H, Williams, Bryan R G
Format: Artigo
Language:Inglês
Published: Blackwell Science Inc 2006
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Original Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1539097/
https://ncbi.nlm.nih.gov/pubmed/16895559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2567.2006.02403.x
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