Novel Human Monoclonal Antibody Combination Effectively Neutralizing Natural Rabies Virus Variants and Individual In Vitro Escape Mutants

The need to replace rabies immune globulin (RIG) as an essential component of rabies postexposure prophylaxis is widely acknowledged. We set out to discover a unique combination of human monoclonal antibodies (MAbs) able to replace RIG. Stringent criteria concerning neutralizing potency, affinity, b...

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Detalhes bibliográficos
Main Authors: Bakker, Alexander B. H., Marissen, Wilfred E., Kramer, R. Arjen, Rice, Amy B., Weldon, William C., Niezgoda, Michael, Hanlon, Cathleen A., Thijsse, Sandra, Backus, Harold H. J., de Kruif, John, Dietzschold, Bernhard, Rupprecht, Charles E., Goudsmit, Jaap
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1168753/
https://ncbi.nlm.nih.gov/pubmed/15994800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.14.9062-9068.2005
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