Novel Human Monoclonal Antibody Combination Effectively Neutralizing Natural Rabies Virus Variants and Individual In Vitro Escape Mutants

The need to replace rabies immune globulin (RIG) as an essential component of rabies postexposure prophylaxis is widely acknowledged. We set out to discover a unique combination of human monoclonal antibodies (MAbs) able to replace RIG. Stringent criteria concerning neutralizing potency, affinity, b...

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Main Authors: Bakker, Alexander B. H., Marissen, Wilfred E., Kramer, R. Arjen, Rice, Amy B., Weldon, William C., Niezgoda, Michael, Hanlon, Cathleen A., Thijsse, Sandra, Backus, Harold H. J., de Kruif, John, Dietzschold, Bernhard, Rupprecht, Charles E., Goudsmit, Jaap
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2005
Teme:
Vaccines and Antiviral Agents
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1168753/
https://ncbi.nlm.nih.gov/pubmed/15994800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.14.9062-9068.2005
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