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Specificity of immunoglobulin heavy chain switch correlates with activity of germline heavy chain genes prior to switching.

IgM+ cells cultured from the I.29 B cell lymphoma can be induced with lipopolysaccharide (LPS) or, to a greater extent, with LPS plus anti-idiotype antibody to switch to IgG2a, IgE or IgA expression. The isotype switch is accompanied by rearrangement of immunoglobulin (Ig) heavy (H) chain genes. Her...

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Autori principali: Stavnezer-Nordgren, J, Sirlin, S
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1986
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1166700/
https://ncbi.nlm.nih.gov/pubmed/3007121
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