Immunoglobulin heavy-chain switching may be directed by prior induction of transcripts from constant-region genes.

Immunoglobulin heavy-chain switching is effected by a DNA recombination event that replaces the C mu gene with one of the other heavy-chain constant-region (CH) genes located 3' to the C mu gene. How the specificity of this event is controlled is unknown. However, it has been shown that IgM+ cells c...

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Publié dans:	Proc Natl Acad Sci U S A
Auteurs principaux:	Stavnezer, J, Radcliffe, G, Lin, Y C, Nietupski, J, Berggren, L, Sitia, R, Severinson, E
Format:	Artigo
Langue:	Inglês
Publié:	National Academy of Sciences 1988
Sujets:	Research Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC282261/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2459714/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.85.20.7704
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