Immunoglobulin heavy-chain switching may be directed by prior induction of transcripts from constant-region genes.
Immunoglobulin heavy-chain switching is effected by a DNA recombination event that replaces the C mu gene with one of the other heavy-chain constant-region (CH) genes located 3' to the C mu gene. How the specificity of this event is controlled is unknown. However, it has been shown that IgM+ cells c...
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| Publicat a: | Proc Natl Acad Sci U S A |
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| Autors principals: | , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
1988
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC282261/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2459714/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.85.20.7704 |
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