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The alkylation of 2′-deoxyguanosine and of thymidine with diazoalkanes. Some observations on O-alkylation

The reaction in ether–methanol between 2′-deoxyguanosine and diazomethane or its ethyl or n-butyl homologue gives 1-, O(6)- and 7-alkyl-2′-deoxyguanosine. N(2),O(6)-Dimethyl-2′-deoxyguanosine was also detected. The hydrolysis of the methyl and the ethyl derivatives gives the corresponding alkylguani...

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Détails bibliographiques
Auteurs principaux: Farmer, P. B., Foster, A. B., Jarman, M., Tisdale, M. J.
Format: Artigo
Langue:Inglês
Publié: 1973
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1165805/
https://ncbi.nlm.nih.gov/pubmed/4776868
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