Pretreatment with Granulocyte Colony-Stimulating Factor Attenuates the Inflammatory Response but Not the Bacterial Load in Cerebrospinal Fluid during Experimental Pneumococcal Meningitis in Rabbits

A possible immunomodulatory role of granulocyte colony-stimulating factor (G-CSF) was investigated in an experimental pneumococcal meningitis model in rabbits. Animals were pretreated with G-CSF (10 μg/kg subcutaneously twice a day) starting 48 h before in vivo and ex vivo experiments, causing a fiv...

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Bibliographic Details

Published in:	Infect Immun
Main Authors:	Østergaard, Christian, Benfield, Thomas, Gesser, Borbola, Kharazmi, Arsalan, Frimodt-Møller, Niels, Espersen, Frank, Lundgren, Jens D.
Format:	Artigo
Language:	Inglês
Published:	American Society for Microbiology (ASM) 1999
Subjects:	Host Response and Inflammation
Online Access:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC116528/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10377123/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.67.7.3430-3436.1999
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