Pretreatment with Granulocyte Colony-Stimulating Factor Attenuates the Inflammatory Response but Not the Bacterial Load in Cerebrospinal Fluid during Experimental Pneumococcal Meningitis in Rabbits

A possible immunomodulatory role of granulocyte colony-stimulating factor (G-CSF) was investigated in an experimental pneumococcal meningitis model in rabbits. Animals were pretreated with G-CSF (10 μg/kg subcutaneously twice a day) starting 48 h before in vivo and ex vivo experiments, causing a fiv...

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Bibliographic Details
Main Authors: Østergaard, Christian, Benfield, Thomas, Gesser, Borbola, Kharazmi, Arsalan, Frimodt-Møller, Niels, Espersen, Frank, Lundgren, Jens D.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 1999
Subjects:
Host Response and Inflammation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC116528/
https://ncbi.nlm.nih.gov/pubmed/10377123
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