Mutants of Human Immunodeficiency Virus Type 1 (HIV-1) Reverse Transcriptase Resistant to Nonnucleoside Reverse Transcriptase Inhibitors Demonstrate Altered Rates of RNase H Cleavage That Correlate with HIV-1 Replication Fitness in Cell Culture

Three mutants of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (V106A, V179D, and Y181C), which occur in clinical isolates and confer resistance to nonnucleoside reverse transcriptase inhibitors (NNRTIs), were analyzed for RNA- and DNA-dependent DNA polymerization and RNase H cle...

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Vydáno v:	J Virol
Hlavní autoři:	Archer, Richard H., Dykes, Carrie, Gerondelis, Peter, Lloyd, Amanda, Fay, Philip, Reichman, Richard C., Bambara, Robert A., Demeter, Lisa M.
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	American Society for Microbiology (ASM) 2000
Témata:	Vaccines and Antiviral Agents
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC116350/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10954539/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.74.18.8390-8401.2000
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