Activation of the Lbc Rho Exchange Factor Proto-Oncogene by Truncation of an Extended C Terminus That Regulates Transformation and Targeting

The human lbc oncogene product is a guanine nucleotide exchange factor that specifically activates the Rho small GTP binding protein, thus resulting in biologically active, GTP-bound Rho, which in turn mediates actin cytoskeletal reorganization, gene transcription, and entry into the mitotic S phase...

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Detalhes bibliográficos
Main Authors: Sterpetti, Paola, Hack, Andrew A., Bashar, Mariam P., Park, Brian, Cheng, Sou-De, Knoll, Joan H. M., Urano, Takeshi, Feig, Larry A., Toksoz, Deniz
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 1999
Assuntos:
Cell Growth and Development
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC116062/
https://ncbi.nlm.nih.gov/pubmed/9891067
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