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Cell-Free Degradation of p27(kip1), a G(1) Cyclin-Dependent Kinase Inhibitor, Is Dependent on CDK2 Activity and the Proteasome

Entry into S phase is dependent on the coordinated activation of CDK4,6 and CDK2 kinases. Once a cell commits to S phase, there must be a mechanism to ensure the irreversibility of this decision. The activity of these kinases is inhibited by their association with p27. In many cells, p27 plays a maj...

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Bibliografski detalji
Glavni autori: Nguyen, Hoang, Gitig, Diana M., Koff, Andrew
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 1999
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC116048/
https://ncbi.nlm.nih.gov/pubmed/9891053
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