Activation of NFAT-Dependent Gene Expression by Nef: Conservation among Divergent Nef Alleles, Dependence on SH3 Binding and Membrane Association, and Cooperation with Protein Kinase C-θ

Here we show that the potential to regulate NFAT is a conserved property of different Nef alleles and that Nef residues involved in membrane targeting and SH3 binding are critical for this function. Cotransfection of an activated protein kinase C-θ (PKC-θ) with Nef implicated PKC-θ as a possible phy...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Manninen, Aki, Huotari, Päivi, Hiipakka, Marita, Renkema, G. Herma, Saksela, Kalle
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 2001
Assuntos:	Virus-Cell Interactions
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC115932/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11222731/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.75.6.3034-3037.2001
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