Electrogenic arginine transport mediates stimulus-secretion coupling in mouse pancreatic beta-cells.

1. We have investigated the mechanism by which L-arginine stimulates membrane depolarization, an increase of intracellular calcium ([Ca2+]i) and insulin secretion in pancreatic beta-cells. 2. L-Arginine failed to affect beta-cell metabolism, as monitored by NAD(P)H autofluorescence. 3. L-Arginine pr...

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Detalhes bibliográficos
Main Authors: Smith, P A, Sakura, H, Coles, B, Gummerson, N, Proks, P, Ashcroft, F M
Formato: Artigo
Idioma:Inglês
Publicado em: 1997
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1159281/
https://ncbi.nlm.nih.gov/pubmed/9130159
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