Novel, Live Attenuated Simian Immunodeficiency Virus Constructs Containing Major Deletions in Leader RNA Sequences

We have constructed a series of simian immunodeficiency virus (SIV) mutants containing deletions within a 97-nucleotide (nt) region of the leader sequence. Deletions in this region markedly decreased the replication capacity in tissue culture, i.e., in both the C8166 and CEMx174 cell lines, as well...

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Bibliografiske detaljer
Main Authors: Guan, Yongjun, Whitney, James B., Liang, Chen, Wainberg, Mark A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2001
Fag:
Replication
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC115902/
https://ncbi.nlm.nih.gov/pubmed/11222701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.75.6.2776-2785.2001
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