A heterodimer-selective agonist shows in vivo relevance of G protein-coupled receptor dimers

There has been much speculation regarding the functional relevance of G protein-coupled receptor heterodimers, primarily because demonstrating their existence in vivo has proven to be a considerable challenge. Here we show that the opioid agonist ligand 6′-guanidinonaltrindole (6′-GNTI) has the uniq...

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Bibliografiske detaljer
Main Authors: Waldhoer, Maria, Fong, Jamie, Jones, Robert M., Lunzer, Mary M., Sharma, Shiv K., Kostenis, Evi, Portoghese, Philip S., Whistler, Jennifer L.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2005
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1157030/
https://ncbi.nlm.nih.gov/pubmed/15932946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0501112102
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