Transcription Factor NF-κB Differentially Regulates Death Receptor 5 Expression Involving Histone Deacetylase 1

The transcription factor nuclear factor κB (NF-κB) regulates the expression of both antiapoptotic and proapoptotic genes. Death receptor 5 (DR5, TRAIL-R2) is a proapoptotic protein considered to be a potential target for cancer therapy, and its expression is mediated by NF-κB. The mechanism of NF-κB...

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Detalhes bibliográficos
Main Authors: Shetty, Shashirekha, Graham, Bonnie A., Brown, Jennifer G., Hu, Xiaojie, Vegh-Yarema, Nicolette, Harding, Gary, Paul, James T., Gibson, Spencer B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1156987/
https://ncbi.nlm.nih.gov/pubmed/15964798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.13.5404-5416.2005
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