A single aspartate residue is involved in both intrinsic gating and blockage by Mg2+ of the inward rectifier, IRK1.

1. We describe the effects on channel function of changing an aspartate residue (Asp172) in a membrane-spanning alpha-helix of the murine inward rectifier, IRK1, by site-directed mutagenesis. 2. Alteration of Asp172 to Glu (charged) or to Gln or Asn (polar but uncharged) produced functional channels...

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Detalhes bibliográficos
Main Authors: Stanfield, P R, Davies, N W, Shelton, P A, Sutcliffe, M J, Khan, I A, Brammar, W J, Conley, E C
Formato: Artigo
Idioma:Inglês
Publicado em: 1994
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1155640/
https://ncbi.nlm.nih.gov/pubmed/7965824
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