Specificity and mechanism of the histone methyltransferase Pr-Set7

Methylation of lysine residues of histones is an important epigenetic mark that correlates with functionally distinct regions of chromatin. We present here the crystal structure of a ternary complex of the enzyme Pr-Set7 (also known as Set8) that methylates Lys 20 of histone H4 (H4-K20). We show tha...

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Main Authors: Xiao, Bing, Jing, Chun, Kelly, Geoff, Walker, Philip A., Muskett, Frederick W., Frenkiel, Thomas A., Martin, Stephen R., Sarma, Kavitha, Reinberg, Danny, Gamblin, Steven J., Wilson, Jonathan R.
Formato: Artigo
Idioma:Inglês
Publicado: Cold Spring Harbor Laboratory Press 2005
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Research Papers
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1151661/
https://ncbi.nlm.nih.gov/pubmed/15933069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1315905
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