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PIASy mediates SUMO-2 conjugation of Topoisomerase-II on mitotic chromosomes
Here we show that the PIASy protein is specifically required for mitotic modification of Topoisomerase-II by SUMO-2 conjugation in Xenopus egg extracts. PIASy was unique among the PIAS family members in its capacity to bind mitotic chromosomes and recruit Ubc9 onto chromatin. These properties were e...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2005
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1150894/ https://ncbi.nlm.nih.gov/pubmed/15933717 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600700 |
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