Global and Hox-specific roles for the MLL1 methyltransferase

The mixed-lineage leukemia (MLL1/ALL-1/HRX) histone methyltransferase is involved in the epigenetic maintenance of transcriptional memory and the pathogenesis of human leukemias. To understand its role in cell type specification, we determined the human genomic binding sites of MLL1. We found that M...

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Библиографические подробности
Главные авторы: Guenther, Matthew G., Jenner, Richard G., Chevalier, Brett, Nakamura, Tatsuya, Croce, Carlo M., Canaani, Eli, Young, Richard A.
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2005
Предметы:
Biological Sciences
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC1150839/
https://ncbi.nlm.nih.gov/pubmed/15941828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0503072102
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